Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 5/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HCK | P08631 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20079126 | 0.85 | CDK8 (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL18853774 | 0.82 | FEN1 (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL15730613 | 0.82 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL23501942 | 0.81 | METAP2 (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGEGFR | |
| SCHEMBL20078968 | 0.78 | NUDT1 (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL14487912 | 0.76 | CDK8 (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL415099 | 0.75 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL16268130 | 0.74 | CDK8 (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL4831501 | 0.74 | CDK8 (0.81) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL13086836 | 0.73 | CDK8 (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370358-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180194746-A1 | Compounds For the Treatment of HIV | GILEAD SCIENCES, INC. | 2018-07-12 | — | — | US | disclosed |
| US-9944619-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2018-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370358-B2 | Compounds for the treatment of HIV | CCR5, NPC1, FURIN | PIK3CA 566/4885PIK3CD 1017/4885PIK3CB 1256/4885 |
| US-20180194746-A1 | Compounds For the Treatment of HIV | CCR5, NPC1, FURIN | PIK3CA 566/4885PIK3CD 1017/4885PIK3CB 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.