Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 8/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23501971 | 0.79 | GRIA1 (0.60) | GRIA1CACNG8CRBNCYP1A2CYP11B1 | |
| SCHEMBL14555416 | 0.73 | MEN1 (0.46) | PARP10PARP11BRD4CREBBP | |
| SCHEMBL18853781 | 0.70 | FYN (0.45) | — | |
| SCHEMBL18189605 | 0.67 | GLO1 (0.57) | GRIA1CACNG8CRBNCYP1A2CYP11B1 | |
| SCHEMBL15730139 | 0.66 | GRIA1 (0.67) | GRIA1CACNG8CRBNCYP1A2CYP11B1 | |
| SCHEMBL29899628 | 0.66 | GRIA1 (0.51) | GRIA1CACNG8CRBNCYP1A2CYP11B1 | |
| SCHEMBL29849643 | 0.66 | GRIA1 (0.55) | TDP2GRIA1CACNG8CRBNCYP1A2 | |
| SCHEMBL14484708 | 0.66 | CRBN (0.42) | GRIA1CACNG8CRBNCYP1A2CYP11B1 | |
| SCHEMBL18010789 | 0.65 | TDP2 (1.00) | TDP2CRBNPARP10PARP11 | |
| SCHEMBL14487503 | 0.65 | GRIA1 (0.45) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944619-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2018-04-17 | — | — | US | disclosed |