Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 8/20 | 0.55 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29899618 | 0.85 | GRIA1 (0.56) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL23143533 | 0.83 | GRIA1 (0.59) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29899612 | 0.83 | GRIA1 (0.59) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29899628 | 0.83 | GRIA1 (0.51) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL15730139 | 0.81 | GRIA1 (0.67) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL18189605 | 0.79 | GLO1 (0.57) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL23501971 | 0.79 | GRIA1 (0.60) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL21517844 | 0.75 | PGR (0.56) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL21517849 | 0.75 | GRIA1 (0.62) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL30272860 | 0.74 | METAP2 (0.41) | CYP1A2CYP11B1CYP11B2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034526-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Agency for Science, Technology and Research (A*STAR) (SG) | 2022-08-03 | — | — | EP | disclosed |