Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 7/20 | 0.60 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 3/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15730139 | 0.84 | GRIA1 (0.67) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29899612 | 0.82 | GRIA1 (0.59) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL23143533 | 0.82 | GRIA1 (0.59) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL18189605 | 0.80 | GLO1 (0.57) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29899628 | 0.79 | GRIA1 (0.51) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL20052023 | 0.79 | TDP2 (0.46) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29849643 | 0.79 | GRIA1 (0.55) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL14487503 | 0.79 | GRIA1 (0.45) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL14487497 | 0.79 | GRIA1 (0.45) | GRIA1CACNG8CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL23502017 | 0.76 | PRKCI (0.50) | TGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2023-01-12 | — | — | US | disclosed |
| US-11034668-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2021-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034668-B2 | Compounds for the treatment of HIV | CCR5, NPC1, FURIN | GRIA1 2928/4885CACNG8 4093/4885CYP1A2 489/4885 |
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | GRIA1 2928/4885CACNG8 4093/4885CYP1A2 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.