Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538454 | 0.89 | GPR119 (0.42) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL20053606 | 0.88 | HRH3 (0.42) | GPR119STAT3HRH3 | |
| SCHEMBL15538636 | 0.87 | GPR119 (0.43) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL20053597 | 0.87 | GPR119 (0.40) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL20053595 | 0.86 | GPR119 (0.53) | GPR119STAT3ALDH1A1HPGDHRH3 | |
| SCHEMBL15538269 | 0.86 | SCN9A (0.46) | GPR119 | |
| SCHEMBL15538263 | 0.86 | SCN9A (0.46) | GPR119 | |
| SCHEMBL20053619 | 0.85 | GPR119 (0.60) | GPR119HPGDKDM4EHRH3CYP4F2 | |
| SCHEMBL21534646 | 0.85 | GPR119 (0.59) | GPR119HPGDHRH3CYP4F2CYP4A11 | |
| SCHEMBL15537715 | 0.84 | HRH3 (0.56) | GPR119ALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858986-B1 | PIPERIDINE DERIVATIVES AS GPR119 AGONISTS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-9944600-B2 | Piperidine derivatives for GPR119 agonist | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-04-17 | — | — | US | disclosed |