Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19557891 | 0.81 | MTNR1A (0.42) | MTNR1AMTNR1BALDH1A1MAPK1HPGD | |
| SCHEMBL4269765 | 0.77 | ALDH1A1 (0.48) | MTNR1AMTNR1BALDH1A1MAPK1HPGD | |
| SCHEMBL16793904 | 0.76 | PTGER1 (0.56) | ALDH1A1MAPK1LMNAKMT2ATSHR | |
| SCHEMBL3448675 | 0.76 | ALDH1A1 (0.47) | MTNR1AMTNR1BALDH1A1MAPK1LMNA | |
| SCHEMBL22350387 | 0.73 | TP53 (0.47) | MTNR1AMTNR1BALDH1A1LMNAKMT2A | |
| SCHEMBL8399042 | 0.72 | SMN1; SMN2 (0.39) | MTNR1AMTNR1BALDH1A1MAPK1HPGD | |
| SCHEMBL29970923 | 0.72 | TAAR1 (0.53) | CYP1A2L3MBTL1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6378 | 0.72 | TAAR1 (0.53) | CYP1A2L3MBTL1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL16814117 | 0.71 | MTNR1A (0.52) | MTNR1AMTNR1BALDH1A1LMNAKDM4E | |
| SCHEMBL18340892 | 0.71 | L3MBTL1 (0.50) | ALDH1A1MAPK1HPGDLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080103-B1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN MA INC (US) | 2018-04-18 | — | — | EP | disclosed |