Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20054554 | 1.00 | AAK1 (0.46) | AAK1CACNA1BCACNA1HRAD52UBE2N | |
| SCHEMBL20054430 | 0.92 | AAK1 (0.41) | AAK1CACNA1BCACNA1HRAD52UBE2N | |
| SCHEMBL20054433 | 0.87 | AAK1 (0.52) | AAK1CACNA1HRAD52UBE2NIDO1 | |
| SCHEMBL20054434 | 0.86 | SCN10A (0.38) | AAK1CACNA1HRAD52UBE2NIDO1 | |
| SCHEMBL12648128 | 0.81 | NLN (0.41) | PDE10A | |
| SCHEMBL20054383 | 0.81 | PDE10A (0.37) | PDE10A | |
| SCHEMBL19414719 | 0.80 | MAPT (0.46) | AAK1RAD52UBE2NIDO1MAPT | |
| SCHEMBL20054552 | 0.77 | NLN (0.43) | PDE10A | |
| SCHEMBL20055263 | 0.76 | USP7 (0.47) | AAK1MAPTKDM4EPKMMEN1 | |
| SCHEMBL20055644 | 0.76 | AAK1 (0.47) | AAK1CACNA1BMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019196-B1 | COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-06 | — | — | EP | disclosed |
| EP-2802326-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-04-18 | — | — | EP | disclosed |