Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20054477 | 0.79 | PDE10A (0.43) | PDE10A | |
| SCHEMBL12648128 | 0.79 | NLN (0.41) | PDE10ASCN10ASCN5ASCN1AKCNH2 | |
| SCHEMBL20054552 | 0.78 | NLN (0.43) | PDE10ASCN10ASCN5A | |
| SCHEMBL20054471 | 0.77 | NLN (0.42) | PDE10ASCN10ASCN5A | |
| SCHEMBL15114364 | 0.77 | SHBG (0.36) | SHBGAPPSCN10ANR1I2HDAC6 | |
| SCHEMBL20054578 | 0.77 | SHBG (0.36) | SHBGAPPSCN10ANR1I2HDAC6 | |
| SCHEMBL20054412 | 0.71 | GSK3B (0.49) | NR1I2KCNH2 | |
| SCHEMBL20055405 | 0.70 | TRPV1 (0.46) | PDE10ASCN10ASCN5A | |
| SCHEMBL2562957 | 0.70 | PDE10A (0.64) | PDE10ASCN2A | |
| SCHEMBL20054430 | 0.68 | AAK1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019196-B1 | COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-06 | — | — | EP | disclosed |
| EP-2802326-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-04-18 | — | — | EP | disclosed |