Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.57 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.48 |
| ▸ | HSD17B14 | Q9BPX1 | 4/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20056636 | 0.79 | ESR2 (0.53) | ESR2TLR8MEN1KMT2A | |
| SCHEMBL22717252 | 0.79 | TLR8 (0.56) | ESR2TLR8MEN1KMT2AHSD17B1 | |
| SCHEMBL12668310 | 0.77 | HSD17B1 (0.60) | ESR2HSD17B1HSD17B2HSD17B14ESR1 | |
| SCHEMBL171059 | 0.77 | — | — | |
| SCHEMBL16574098 | 0.77 | MAP4K4 (0.48) | PIM1 | |
| SCHEMBL5843930 | 0.76 | ALOX15 (0.53) | ESR2MEN1KMT2AESR1PIM1 | |
| SCHEMBL7870739 | 0.76 | PTGS2 (0.44) | MEN1KMT2APIM1 | |
| Potassium SCHEMBL30562954 | 0.75 | ESR2 (0.59) | ESR2TLR8MEN1KMT2AESR1 | |
| SCHEMBL30991479 | 0.75 | ESR2 (0.59) | ESR2TLR8MEN1KMT2AESR1 | |
| SCHEMBL27457915 | 0.75 | ESR2 (0.59) | ESR2TLR8MEN1KMT2AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970353-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2018-04-18 | — | — | EP | disclosed |