Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005668 | 1.00 | KMT2A (0.60) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL3097025 | 0.89 | MEN1 (0.54) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL3097012 | 0.89 | MEN1 (0.54) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL13646963 | 0.85 | MEN1 (0.61) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL12196952 | 0.84 | MEN1 (0.60) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL14892650 | 0.80 | RECQL (0.50) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL14892651 | 0.80 | RECQL (0.50) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL12900375 | 0.80 | MEN1 (0.63) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL13647052 | 0.78 | MEN1 (0.54) | KMT2AMEN1MAPTRAB9AHPGD | |
| SCHEMBL18114753 | 0.76 | KDM4E (0.53) | KMT2AMEN1MAPTRAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240492-B1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | ORGANON NV (NL) | 2011-10-05 | — | — | EP | claimed |
| US-7964739-B2 | Through a stilbene derivative, to a pyrrolidine intermediate, followed by cyclization; asenapine is an antipsychotic agent; industrial scale | N.V. ORGANON (NL) | 2011-06-21 | — | — | US | claimed |
| EP-2240492-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. Organon (NL) | 2010-10-20 | — | — | EP | claimed |
| US-7750167-B2 | Process for the preparation of asenapine and intermediate products used in said process | N.V. ORGANON (NL) | 2010-07-06 | — | — | US | claimed |
| EP-2044076-B1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | ORGANON NV (NL) | 2009-10-14 | — | — | EP | claimed |
| US-20090227803-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON | 2009-09-10 | — | — | US | claimed |
| WO-2009087058-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2009-07-16 | — | — | WO | claimed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | claimed |
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| EP-4015519-A1 | METHOD OF PREPARING ASENAPINE | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021027813-A1 | METHOD OF PREPARING ASENAPINE | 浙江奥翔药业股份有限公司 | 2021-02-18 | — | — | WO | disclosed |
| US-8227623-B2 | Process for the preparation of asenapine and intermediate products used in said process | MSD OSS B.V. (NL) | 2012-07-24 | — | — | US | disclosed |
| US-8227623-B2 | Process for the preparation of asenapine and intermediate products used in said process | MSD OSS B.V. (NL) | 2012-07-24 | — | — | US | disclosed |
| US-8227623-B2 | Process for the preparation of asenapine and intermediate products used in said process | MSD OSS B.V. (NL) | 2012-07-24 | — | — | US | disclosed |
| EP-2044076-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. Organon (NL) | 2009-04-08 | — | — | EP | disclosed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | disclosed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | disclosed |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2008-01-10 | — | — | US | disclosed |
| WO-2008003460-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. ORGANON (NL) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008003460-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS. | N.V. ORGANON (NL) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159549-A1 | METHOD FOR PREPARATION OF ASENAPINE | CYP3A5, QDPR, SPR | KMT2A 2211/4885MEN1 2222/4885MAPT 727/4885 |
| US-20090227803-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | DHPS, CYP3A5, PNMT | KMT2A 1335/4885MEN1 4096/4885MAPT 1521/4885 |
| US-20080009619-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | DHPS, CYP3A5, PNMT | KMT2A 1335/4885MEN1 4096/4885MAPT 1521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.