Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003138 | 0.93 | EDNRB (0.41) | LMNAMAPK1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2005689 | 0.93 | MAPK1 (0.44) | LMNAMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL2006961 | 0.91 | LMNA (0.40) | LMNAMAPK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2005841 | 0.90 | MAPK1 (0.47) | LMNAMAPK1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2008151 | 0.90 | LMNA (0.39) | LMNAMAPK1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2007585 | 0.90 | LMNA (0.49) | LMNAMAPK1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2003876 | 0.90 | SLC26A4 (0.35) | LMNASMN1; SMN2CYP3A4CYP2C9POLB | |
| SCHEMBL1999740 | 0.88 | LMNA (0.45) | LMNAMAPK1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2011749 | 0.88 | LMNA (0.38) | LMNASMN1; SMN2KDM4EALDH1A1TSHR | |
| SCHEMBL2005303 | 0.88 | SLC26A4 (0.38) | LMNASMN1; SMN2CYP3A4CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |