Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 9/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005932 | 0.92 | MEN1 (0.46) | ALOX5APALOX5LMNAMAPTALDH1A1 | |
| SCHEMBL2004203 | 0.92 | ALOX5AP (0.45) | ALOX5APALOX5ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL2007346 | 0.92 | ALOX5AP (0.39) | ALOX5APALOX5LMNAMAPTALDH1A1 | |
| SCHEMBL2002164 | 0.91 | ALOX5AP (0.45) | ALOX5APALOX5LMNAMAPTALDH1A1 | |
| SCHEMBL1997676 | 0.89 | ALOX5AP (0.45) | ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL2006285 | 0.89 | HSD17B10 (0.39) | ALOX5APALOX5LMNAMAPTALDH1A1 | |
| SCHEMBL2005411 | 0.89 | ALOX5AP (0.42) | ALOX5APALOX5LMNAMAPTALDH1A1 | |
| SCHEMBL2005841 | 0.88 | MAPK1 (0.47) | ALOX5APALOX5LMNAMAPTALDH1A1 | |
| SCHEMBL2001978 | 0.88 | FAAH (0.45) | ALOX5APALOX5MAPTALDH1A1CYP2C9 | |
| SCHEMBL2007363 | 0.87 | ALOX5AP (0.40) | ALOX5APALOX5LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |