Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006816 | 0.94 | LMNA (0.42) | LMNAMAPK1PKMALDH1A1KDM4E | |
| SCHEMBL2006431 | 0.91 | MAPK1 (0.50) | LMNAMAPK1PKMFAAHCES1 | |
| SCHEMBL2009227 | 0.91 | CYP1A2 (0.42) | LMNAMAPK1FAAHCES1ALDH1A1 | |
| SCHEMBL2003530 | 0.89 | MAPK1 (0.45) | LMNAMAPK1PKMFAAHCES1 | |
| SCHEMBL2000262 | 0.89 | MAPK1 (0.48) | LMNAMAPK1PKMFAAHCES1 | |
| SCHEMBL2002147 | 0.88 | ALDH1A1 (0.37) | LMNAMAPK1ALDH1A1KDM4EMITF | |
| SCHEMBL2006683 | 0.88 | MAPK1 (0.47) | LMNAMAPK1PKMFAAHKDM4E | |
| SCHEMBL2002436 | 0.88 | LMNA (0.55) | LMNAMAPK1PKMFAAHCES1 | |
| SCHEMBL2004831 | 0.87 | PTGES2 (0.38) | LMNAMAPK1ALDH1A1KDM4EHIF1A | |
| SCHEMBL2002954 | 0.87 | LMNA (0.54) | LMNAMAPK1PKMFAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |