Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012451 | 0.94 | LMNA (0.42) | MAPK1LMNAPKMTSHRKMT2A | |
| SCHEMBL2002838 | 0.93 | LMNA (0.45) | MAPK1LMNAPKMTSHRKMT2A | |
| SCHEMBL2005834 | 0.91 | LMNA (0.39) | MAPK1LMNAPKMTSHRALDH1A1 | |
| SCHEMBL2002445 | 0.90 | LMNA (0.43) | MAPK1LMNAPKMTSHRKMT2A | |
| SCHEMBL2009477 | 0.90 | LMNA (0.42) | MAPK1LMNAPKMTSHRKMT2A | |
| SCHEMBL2004704 | 0.89 | LMNA (0.38) | MAPK1LMNAPKMTSHRALDH1A1 | |
| SCHEMBL2004635 | 0.89 | MAPK1 (0.48) | MAPK1LMNAPKMTSHRKMT2A | |
| SCHEMBL2005876 | 0.89 | LMNA (0.50) | MAPK1LMNAPKMKMT2AALDH1A1 | |
| SCHEMBL2003403 | 0.89 | LMNA (0.38) | MAPK1LMNATSHRKMT2AALDH1A1 | |
| SCHEMBL2007059 | 0.88 | MAPK1 (0.41) | MAPK1LMNAPKMTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |