Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11581329 | 0.85 | MEN1 (0.38) | ALOX5MAPTMEN1KMT2APDK2 | |
| SCHEMBL29836971 | 0.83 | SKP2 (0.46) | ALDH1A1MEN1KMT2ACA2RAB9A | |
| SCHEMBL11580037 | 0.81 | KMT2A (0.37) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL8390740 | 0.78 | CA2 (0.40) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8390737 | 0.77 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL31142510 | 0.74 | MEN1 (0.39) | MEN1KMT2ATDP1CASP3RAB9A | |
| SCHEMBL661200 | 0.74 | MEN1 (0.39) | MEN1KMT2ATDP1CASP3RAB9A | |
| SCHEMBL10035871 | 0.74 | MEN1 (0.39) | MEN1KMT2ATDP1CASP3RAB9A | |
| SCHEMBL18386310 | 0.74 | SMN1; SMN2 (0.42) | MAPTMEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL4358306 | 0.73 | HSD17B10 (0.36) | MEN1KMT2APDK2TDP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835632-B2 | Methods to increase the photostability of dyes | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835632-B2 | Methods to increase the photostability of dyes | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2014-09-16 | — | — | US | disclosed |
| US-7964361-B2 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2011-06-21 | — | — | US | disclosed |
| US-20110046000-A1 | METHODS TO INCREASE THE PHOTOSTABILITY OF DYES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-02-24 | — | — | US | disclosed |
| US-20110046000-A1 | METHODS TO INCREASE THE PHOTOSTABILITY OF DYES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-02-24 | — | — | US | disclosed |
| US-20090281279-A1 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2008157762-A2 | METHODS TO INCREASE THE PHOTOSTABILITY OF DYES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-12-24 | — | — | WO | disclosed |
| US-7408062-B2 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2008-08-05 | — | — | US | disclosed |
| US-20070243527-A9 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE MELLON UNIVERSITY | 2007-10-18 | — | — | US | disclosed |
| US-6686145-B1 | IMPARTING FLUORESCENT PROPERTIES TO TARGET MATERIALS BY COVALENT AND NONCOVALENT ASSOCIATION | CARNEGIE MELLON UNIVERSITY | 2004-02-03 | — | — | US | disclosed |
| US-20030224391-A1 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY | 2003-12-04 | — | — | US | disclosed |
| EP-1042407-B1 | RIGIDIZED TRIMETHINE CYANINE DYES | UNIV CARNEGIE MELLON (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6133445-A | USEFUL FOR IMPARTING FLUORESCENT PROPERTIES TO TARGET MATERIALS | CARNEGIE MELLON UNIVERSITY (US) | 2000-10-17 | — | — | US | disclosed |
| EP-1042407-A1 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE-MELLON UNIVERSITY (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031181-A1 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE MELLON UNIVERSITY (US) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243527-A9 | RIGIDIZED TRIMETHINE CYANINE DYES | SIGMAR1, CBR1, NR0B1 | KDM4E 771/4885ALDH1A1 1428/4885ALOX5 2278/4885 |
| US-20090281279-A1 | Rigidized trimethine cyanine dyes | CD47, TLN1, TPM4 | KDM4E 174/4885ALDH1A1 3193/4885ALOX5 4785/4885 |
| US-20110046000-A1 | METHODS TO INCREASE THE PHOTOSTABILITY OF DYES | PTMS, ACP1, SNRPE | KDM4E 3420/4885ALDH1A1 3978/4885ALOX5 4449/4885 |
| US-20030224391-A1 | Rigidized trimethine cyanine dyes | CBR1, TH, CBR3 | KDM4E 408/4885ALDH1A1 2154/4885ALOX5 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.