Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 2/20 | 1.00 |
| ▸ | APBA1 | Q02410 | 2/20 | 1.00 |
| ▸ | CCR6 | P51684 | 1/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4407371 | 0.89 | ALDH1A1 (0.79) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL2002688 | 0.85 | ALDH1A1 (0.73) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL4408152 | 0.85 | ALDH1A1 (0.74) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL2005150 | 0.83 | MAPT (0.72) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL10977161 | 0.82 | ALDH1A1 (0.70) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL2003891 | 0.81 | ALDH1A1 (1.00) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL2010483 | 0.81 | ALDH1A1 (0.70) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL4408113 | 0.81 | ALDH1A1 (0.68) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL4407904 | 0.81 | ALDH1A1 (0.68) | ALDH1A1HTTHPGDMAPTCACNA1B | |
| SCHEMBL2006912 | 0.80 | ALDH1A1 (0.67) | ALDH1A1HTTHPGDMAPTCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964625-B2 | Antibiotics comprising bis(1-aryl-5-tetrazoly1)methane derivatives | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2011-06-21 | — | — | US | disclosed |
| EP-1937257-B1 | NOVEL ANTIBIOTICS COMPRISING BIS(1-ARYL-5-TETRAZ0LYL)METHANE DERIVATIVES | TNO (NL) | 2010-12-08 | — | — | EP | disclosed |
| US-20080280964-A1 | Novel Antibiotics Comprising Bis(1-Aryl-5-Tetrazolyl)Methane Derivatives | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2008-11-13 | — | — | US | disclosed |
| EP-1769796-A1 | Novel antibiotics comprising bis(1-aryl-5-tetrazolyl)methane derivatives | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO (NL) | 2007-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280964-A1 | Novel Antibiotics Comprising Bis(1-Aryl-5-Tetrazolyl)Methane Derivatives | LAS1L, AAAS, RPS5 | ALDH1A1 3743/4885HTT 3686/4885HPGD 4361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.