SCHEMBL20062878

SCHEMBL20062878

c1ccc(N2C(=C3N(c4ccccn4)c4ccccc4N3c3ccccn3)N(c3ccccn3)c3ccccc32)nc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.53
GAA P10253 2/20 0.46
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 2/20 0.46
POLB P06746 3/20 0.43
PLD1 Q13393 1/20 0.42
MAPK1 P28482 1/20 0.42
EP300 Q09472 1/20 0.41
KAT2B Q92831 1/20 0.41
CHEK1 O14757 1/20 0.41
AURKA O14965 1/20 0.41
DAPK3 O43293 1/20 0.41
JAK2 O60674 1/20 0.41
PRKD3 O94806 1/20 0.41
MAP4K4 O95819 1/20 0.41
PAK4 O96013 1/20 0.41
ABL1 P00519 1/20 0.41
NTRK1 P04629 1/20 0.41
FYN P06241 1/20 0.41
CSF1R P07333 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18199843 0.82 SMN1; SMN2 (0.55) SMN1; SMN2GAAALDH1A1KDM4EPOLB
SCHEMBL13296025 0.81 SMN1; SMN2 (0.53) SMN1; SMN2GAAALDH1A1KDM4EPOLB
SCHEMBL20062939 0.78 RPS6KA5 (0.42) SMN1; SMN2ROCK1CYP1A2
SCHEMBL20071867 0.78 SMN1; SMN2 (0.43) SMN1; SMN2KDM4ECHEK1AURKADAPK3
SCHEMBL20062935 0.77 L3MBTL1 (0.46) SMN1; SMN2ALDH1A1KDM4EPOLBLMNA
SCHEMBL20062927 0.76 HTT (0.42) SMN1; SMN2GAAALDH1A1KDM4EPOLB
SCHEMBL5487603 0.75 SMN1; SMN2 (0.47) SMN1; SMN2GAAALDH1A1KDM4EPOLB
SCHEMBL2498937 0.75 SMN1; SMN2 (0.51) SMN1; SMN2GAAALDH1A1KDM4EPOLB
SCHEMBL30462881 0.75 SMN1; SMN2 (0.47) SMN1; SMN2GAAALDH1A1KDM4EPOLB
SCHEMBL6024373 0.75 SMN1; SMN2 (0.47) SMN1; SMN2GAAALDH1A1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180108691-A1 ORGANIC PHOTOELECTRIC CONVERSION ELEMENT, OPTICAL AREA SENSOR, IMAGING DEVICE, AND IMAGING APPARATUS CANON KABUSHIKI KAISHA (JP) 2018-04-19 US disclosed