Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.39 |
| ▸ | GLRB | P48167 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064317 | 0.83 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CSYK | |
| SCHEMBL6876750 | 0.83 | PDE4D (0.56) | PDE4BPDE4DPDE4APDE4CSYK | |
| SCHEMBL14345864 | 0.79 | ALDH1A1 (0.51) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL17708433 | 0.75 | SYK (0.47) | PDE4BPDE4DPDE4APDE4CSYK | |
| SCHEMBL12180465 | 0.74 | ACHE (0.65) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL15337428 | 0.74 | ALDH1A1 (0.43) | PDE4BPDE4DPDE4APDE4CSYK | |
| SCHEMBL16956686 | 0.73 | MAPT (0.46) | PDE4BALDH1A1MEN1LMNAMAPT | |
| SCHEMBL21709998 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MEN1LMNAMAPTMAPK1 | |
| SCHEMBL15521568 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MEN1LMNAMAPTMAPK1 | |
| SCHEMBL16120951 | 0.73 | HTR2C (0.45) | SLC6A4HTR2CHTR2BHTR6SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |