Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 12/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21222149 | 0.85 | PTGES (0.40) | HPGDSPTGESDRD2IRAK4 | |
| SCHEMBL21222148 | 0.85 | PTGES (0.40) | HPGDSPTGESDRD2IRAK4 | |
| SCHEMBL20064509 | 0.82 | NPC1 (0.50) | MEN1NPC1RAB9AKMT2AHPGDS | |
| SCHEMBL20065559 | 0.82 | NPC1 (0.41) | MEN1NPC1RAB9AKMT2AHPGDS | |
| SCHEMBL21222553 | 0.81 | DRD2 (0.39) | HPGDSPTGESENPP2DRD2 | |
| SCHEMBL20065617 | 0.81 | DRD2 (0.39) | HPGDSPTGESENPP2DRD2 | |
| SCHEMBL20064607 | 0.73 | MEN1 (0.40) | MEN1NPC1RAB9AKMT2AHPGDS | |
| SCHEMBL21222050 | 0.70 | HPGDS (0.44) | HPGDSALDH1A1GAA | |
| SCHEMBL20064724 | 0.70 | HPGDS (0.44) | HPGDSALDH1A1GAA | |
| SCHEMBL21222471 | 0.70 | PTGES (0.47) | RAB9AHPGDSPTGESDRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |