Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064615 | 0.76 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL806505 | 0.75 | ALDH1A1 (0.47) | PDE4AHTR6MAOB | |
| SCHEMBL3956231 | 0.70 | HTR6 (0.49) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL28158264 | 0.67 | LMNA (0.41) | PDE4APDE4BPDE4CPDE4DCSNK2A1 | |
| SCHEMBL2056246 | 0.67 | CYP1A2 (0.40) | PDE4ACSNK2A1MAOB | |
| SCHEMBL13678433 | 0.66 | CSNK2A1 (0.55) | SYKCSNK2A1KMOFPR2 | |
| SCHEMBL16440160 | 0.66 | ACHE (0.59) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL20204758 | 0.66 | SYK (0.48) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL4363589 | 0.66 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL20064205 | 0.65 | ACHE (0.42) | PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |