Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064665 | 0.86 | CYP1A2 (0.44) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL20723220 | 0.79 | CYP1A2 (0.47) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL20065122 | 0.74 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL20064712 | 0.73 | GAA (0.48) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL21189608 | 0.73 | CYP1A2 (0.42) | KDM4EALDH1A1HPGDCYP1A2MAPT | |
| SCHEMBL21177528 | 0.72 | ADORA3 (0.42) | NPC1RAB9ASMN1; SMN2CYP1A2MAPT | |
| SCHEMBL21177355 | 0.71 | ADORA3 (0.42) | ALDH1A1SMN1; SMN2CYP1A2MAPTGABRA2 | |
| SCHEMBL20723321 | 0.69 | MAPT (0.39) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL14124198 | 0.69 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL20722996 | 0.69 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2CYP1A2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105529-A1 | RSV ANTIVIRAL PYRAZOLO- AND TRIAZOLO-PYRIMIDINE COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105529-A1 | RSV ANTIVIRAL PYRAZOLO- AND TRIAZOLO-PYRIMIDINE COMPOUNDS | ZC3HAV1, MAVS, TYMP | KDM4E 3598/4885ALDH1A1 3193/4885HSD17B10 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.