Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 2/20 | 0.30 |
| ▸ | SKP1 | P63208 | 2/20 | 0.30 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18779330 | 0.88 | MTNR1A (0.34) | MTNR1AMTNR1BPAX8PDPK1BRD4 | |
| SCHEMBL17133441 | 0.79 | KMT2A (0.36) | MTNR1AMTNR1BPAX8PDPK1BRD4 | |
| SCHEMBL17111552 | 0.78 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTNPC1GAA | |
| SCHEMBL17111881 | 0.78 | KMT2A (0.39) | ALDH1A1LMNAKMT2AMAPTMAPK1 | |
| SCHEMBL20067069 | 0.77 | MTNR1A (0.39) | MTNR1AMTNR1BPAX8PDPK1BRD4 | |
| SCHEMBL8303054 | 0.75 | ALDH1A1 (0.38) | MTNR1AMTNR1BPAX8CKS1BSKP1 | |
| SCHEMBL20067094 | 0.74 | MTNR1A (0.33) | MTNR1AMTNR1BPAX8BRD4HPGDS | |
| SCHEMBL17111477 | 0.73 | TACR1 (0.38) | MTNR1AMTNR1BPAX8BRD4HPGDS | |
| SCHEMBL3773631 | 0.69 | MAP2K3 (0.47) | PAX8GRM6ALDH1A1KMT2AMAPT | |
| SCHEMBL17336570 | 0.68 | CYP3A4 (0.39) | GBA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105518-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105518-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | NGFR, NTRK2, NGF | MTNR1A 1826/4885MTNR1B 2032/4885PAX8 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.