Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20067069 | 0.86 | MTNR1A (0.39) | ALDH1A1MTNR1AMTNR1BL3MBTL1CKS1B | |
| SCHEMBL17133441 | 0.79 | KMT2A (0.36) | ALDH1A1MTNR1AMTNR1BCKS1BSKP1 | |
| SCHEMBL18779330 | 0.77 | MTNR1A (0.34) | ALDH1A1MTNR1AMTNR1BCKS1BSKP1 | |
| SCHEMBL20067074 | 0.75 | MTNR1A (0.33) | ALDH1A1MTNR1AMTNR1BCKS1BSKP1 | |
| SCHEMBL20067094 | 0.74 | MTNR1A (0.33) | MTNR1AMTNR1BCKS1BSKP1SKP2 | |
| SCHEMBL17111552 | 0.74 | ALDH1A1 (0.35) | ALDH1A1CYP1A2CYP2C19L3MBTL1NPC1 | |
| SCHEMBL17111881 | 0.74 | KMT2A (0.39) | ALDH1A1L3MBTL1NPC1RAB9ATSHR | |
| SCHEMBL17111477 | 0.73 | TACR1 (0.38) | ALDH1A1MTNR1AMTNR1BCKS1BSKP1 | |
| SCHEMBL25262286 | 0.72 | ADORA2A (0.38) | ALDH1A1CYP1A2CYP2C19PKMTSHR | |
| SCHEMBL4919601 | 0.70 | PAX8 (0.37) | ALDH1A1CYP1A2CYP2C19L3MBTL1CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872136-A | Arylheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0891361-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036901-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |