Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 2/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006881 | 1.00 | RORC (0.42) | RORCCYP2C9USP2CYP3A4CYP2D6 | |
| SCHEMBL2002379 | 0.90 | LMNA (0.47) | RORCNR1H3MAPTNR1H2CYP11B1 | |
| SCHEMBL2002378 | 0.90 | LMNA (0.47) | RORCNR1H3MAPTNR1H2CYP11B1 | |
| SCHEMBL2001989 | 0.84 | HPGD (0.48) | RORCTSHRNR1H3MAPTNR1H2 | |
| SCHEMBL2001530 | 0.84 | CRHBP (0.44) | RORCSMN1; SMN2NR1H3NR1H2CPT1A | |
| SCHEMBL2008016 | 0.84 | KMT2A (0.45) | RORCCYP2C9USP2TSHRSMN1; SMN2 | |
| SCHEMBL2002839 | 0.83 | RORC (0.48) | RORCCYP2C9NR1H3MAPTNR1H2 | |
| SCHEMBL13670322 | 0.83 | RORC (0.41) | RORCCYP2C9NR1H3MAPTNR1H2 | |
| SCHEMBL2004171 | 0.83 | EPHX2 (0.47) | RORCHTTNR1H3NR1H2 | |
| SCHEMBL2004004 | 0.82 | RORC (0.47) | RORCCYP2C9NR1H3MAPTNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960377-B2 | Substituted pyridoxazines | CARA THERAPEUTICS, INC. (US) | 2011-06-14 | — | — | US | claimed |