Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CPT1A | P50416 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002378 | 0.90 | LMNA (0.47) | RORCNR1H3NR1H2CYP11B1MAPT | |
| SCHEMBL2002379 | 0.90 | LMNA (0.47) | RORCNR1H3NR1H2CYP11B1MAPT | |
| SCHEMBL13669971 | 0.89 | TDP1 (0.48) | RORCNR1H3NR1H2CYP11B1CPT1A | |
| SCHEMBL2011173 | 0.89 | TDP1 (0.48) | RORCNR1H3NR1H2CYP11B1CPT1A | |
| SCHEMBL4054289 | 0.88 | BRD4 (0.45) | RORCNR1H3NR1H2CYP11B1BRD4 | |
| SCHEMBL2004141 | 0.87 | OPRD1 (0.47) | RORCBRD4BRD2BRD3BRDT | |
| SCHEMBL2002214 | 0.87 | RHOC (0.41) | RORCNR1H3NR1H2CYP11B1CPT1A | |
| SCHEMBL2008212 | 0.86 | KMT2A (0.42) | RORCMAPTCPT1ACYP2C9 | |
| SCHEMBL2008210 | 0.86 | KMT2A (0.42) | RORCMAPTCPT1ACYP2C9 | |
| SCHEMBL12570153 | 0.86 | RAB9A (0.40) | RORCCPT1ACYP2C9BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120660-A2 | SUBSTITUTED PYRIDOXAZINES | CARA THERAPEUTICS, INC. (US) | 2009-10-01 | — | — | WO | disclosed |