Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15648405 | 0.87 | TDO2 (0.42) | TDO2METHRH3GPR119LRRK2 | |
| SCHEMBL20147961 | 0.82 | CHRNB2 (0.40) | PDGFRBPDGFRA | |
| SCHEMBL20147451 | 0.82 | HRH3 (0.52) | HRH3GPR119 | |
| SCHEMBL20158635 | 0.82 | HRH3 (0.46) | PDGFRBPDGFRAHRH3GPR119 | |
| SCHEMBL14634616 | 0.82 | GPR119 (0.45) | GPR119 | |
| SCHEMBL14634615 | 0.82 | GPR119 (0.45) | GPR119 | |
| SCHEMBL20069570 | 0.81 | CHRM4 (0.53) | HRH3TGFBR1ACVR1SMN1; SMN2RAB9A | |
| SCHEMBL20158603 | 0.81 | TDO2 (0.48) | TDO2HRH3TGFBR1ACVR1SMN1; SMN2 | |
| SCHEMBL20069575 | 0.81 | HTR1D (0.47) | TDO2HRH3HTR1DHTR1BHTR1F | |
| SCHEMBL8302494 | 0.78 | NAAA (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |