Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1522066 | 0.86 | NAPRT (0.52) | DRD2RAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL20147938 | 0.83 | ALDH1A1 (0.53) | DRD2LMNASMN1; SMN2TSHRCYP2C19 | |
| SCHEMBL21651967 | 0.83 | DRD2 (0.60) | DRD2KDM4ERAB9ALMNASMN1; SMN2 | |
| SCHEMBL20069164 | 0.83 | KDM4E (0.49) | DRD2KDM4ERAB9ALMNASMN1; SMN2 | |
| SCHEMBL20069616 | 0.83 | POLB (0.53) | KDM4ERAB9ASMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL22857089 | 0.81 | DRD2 (0.49) | DRD2LMNATSHRCYP2C19CYP1A2 | |
| SCHEMBL20224882 | 0.79 | CYP1A2 (0.52) | DRD2LMNASMN1; SMN2TSHRCYP2C19 | |
| SCHEMBL20069615 | 0.78 | ALDH1A1 (0.52) | PDPK1RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL20137661 | 0.78 | TSHR (0.52) | DRD2KDM4ETSHRCYP2C19CYP1A2 | |
| SCHEMBL20069163 | 0.77 | OPRD1 (0.40) | KDM4EPDPK1ALDH1A1KMT2ACETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |