Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | CETP | P11597 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147938 | 0.89 | ALDH1A1 (0.53) | DRD2CETPALDH1A1TSHRCYP2C19 | |
| SCHEMBL20069153 | 0.81 | DRD2 (0.54) | DRD2CETPALDH1A1TSHRCYP2C19 | |
| SCHEMBL20205744 | 0.80 | OPRM1 (0.44) | CETPALDH1A1NPY2RKMT2AATM | |
| SCHEMBL1522066 | 0.80 | NAPRT (0.52) | DRD2CETPALDH1A1TSHRCYP2C19 | |
| SCHEMBL21651967 | 0.77 | DRD2 (0.60) | DRD2TSHRCYP2C19CYP1A2CYP2C9 | |
| SCHEMBL20205761 | 0.77 | KMT2A (0.46) | ALDH1A1LMNAHTTNPSR1MEN1 | |
| SCHEMBL20328008 | 0.74 | CYP1A2 (0.34) | CETPALDH1A1CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL22857073 | 0.74 | ALDH1A1 (0.50) | DRD2CETPALDH1A1TSHRCYP2C19 | |
| SCHEMBL21652031 | 0.74 | POLB (0.50) | ALDH1A1TSHRHTTNPSR1POLB | |
| SCHEMBL20158643 | 0.73 | MAPT (0.60) | ALDH1A1MEN1KMT2AFAAHGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | DRD2 3425/4885CETP 4877/4885ALDH1A1 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.