Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005712 | 0.95 | L3MBTL1 (0.37) | MAPTLMNAALDH1A1ALOX12CYP3A4 | |
| SCHEMBL2007905 | 0.94 | FAAH (0.37) | MAPTLMNAALDH1A1ALOX12CYP3A4 | |
| SCHEMBL2010615 | 0.94 | LMNA (0.41) | MAPTLMNAALDH1A1ALOX12CYP3A4 | |
| SCHEMBL2008751 | 0.92 | MAPT (0.38) | MAPTLMNAALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL2004901 | 0.92 | MAPT (0.36) | MAPTALDH1A1ALOX12CYP3A4TSHR | |
| SCHEMBL2005115 | 0.91 | ALOX5AP (0.37) | MAPTLMNAALDH1A1ALOX12SMN1; SMN2 | |
| SCHEMBL2004795 | 0.89 | MAPT (0.34) | MAPTLMNAALDH1A1ALOX12CYP3A4 | |
| SCHEMBL2000474 | 0.89 | LMNA (0.41) | MAPTLMNAALDH1A1ALOX12CYP3A4 | |
| SCHEMBL2004625 | 0.89 | CYP2C9 (0.40) | MAPTLMNAALDH1A1ALOX12CYP3A4 | |
| SCHEMBL2003216 | 0.86 | LMNA (0.35) | MAPTLMNAALDH1A1ALOX12CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |