Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 8/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008751 | 0.93 | MAPT (0.38) | ALOX5APALOX5LMNAMAPTALDH1A1 | |
| SCHEMBL2005411 | 0.92 | ALOX5AP (0.42) | ALOX5APALOX5SLC26A4LMNAMAPT | |
| SCHEMBL2006959 | 0.91 | MAPT (0.36) | ALOX5APALOX5LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2006472 | 0.91 | ALOX5AP (0.36) | ALOX5APALOX5POLBSLC26A4LMNA | |
| SCHEMBL2007246 | 0.90 | LMNA (0.38) | ALOX5APALOX5POLBSLC26A4LMNA | |
| SCHEMBL2007346 | 0.90 | ALOX5AP (0.39) | ALOX5APALOX5POLBSLC26A4LMNA | |
| SCHEMBL2007905 | 0.89 | FAAH (0.37) | LMNAMAPTSMN1; SMN2ALDH1A1ALOX12 | |
| SCHEMBL2005712 | 0.88 | L3MBTL1 (0.37) | ALOX5APALOX5LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2003876 | 0.88 | SLC26A4 (0.35) | ALOX5APALOX5POLBSLC26A4LMNA | |
| SCHEMBL2010615 | 0.88 | LMNA (0.41) | ALOX5APPOLBLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |