Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069778 | 0.82 | RET (0.36) | CYP2D6 | |
| SCHEMBL20147475 | 0.71 | CCR1 (0.34) | CYP2D6 | |
| SCHEMBL20069560 | 0.71 | CYP2D6 (0.35) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL20147362 | 0.69 | DPP4 (0.35) | CYP2D6KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL16304087 | 0.68 | DRD2 (0.37) | CYP2D6ALDH1A1 | |
| SCHEMBL20147381 | 0.68 | PARP1 (0.33) | CYP2D6 | |
| SCHEMBL20147484 | 0.68 | ALDH1A1 (0.36) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL20711793 | 0.68 | CYP2D6 (0.36) | CYP2D6 | |
| SCHEMBL18705063 | 0.67 | MMP9 (0.33) | CYP2D6 | |
| SCHEMBL22198735 | 0.67 | CYP2D6 (0.38) | CYP2D6KDM4EMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |