Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 3/20 | 0.61 |
| ▸ | TUBB | P07437 | 3/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.61 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.61 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.61 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.61 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.61 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.61 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.61 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.61 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.61 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.61 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.61 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.61 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.61 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23266383 | 0.98 | TUBB1 (0.63) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2007007 | 0.92 | TNKS2 (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7424861 | 0.88 | HTR2A (0.69) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5833688 | 0.84 | HTR2A (0.64) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10774727 | 0.83 | PTGS2 (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10772012 | 0.83 | PTGS2 (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10773005 | 0.83 | PTGS2 (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL20376310 | 0.82 | TNKS2 (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5871797 | 0.81 | TUBB4A (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL23534141 | 0.81 | TUBB4A (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10167259-B2 | Allosteric inhibitors of proteasome and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-01-01 | — | — | US | disclosed |
| US-20160152567-A1 | NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY STEM (US) | 2016-06-02 | — | — | US | disclosed |
| US-20160152567-A1 | NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY STEM (US) | 2016-06-02 | — | — | US | disclosed |
| WO-2008081096-A2 | QUINOLINYL DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTIC COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS HYPOGLYCEMIANT AND HYPOLIPEMIANT AGENTS | LES LABORATOIRES SERVIER (FR) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152567-A1 | NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF | PSME3, PSMB1, PSMB2 | TUBB4A 3061/4885TUBB 2815/4885TUBA3C 3290/4885 |
| US-10167259-B2 | Allosteric inhibitors of proteasome and methods of use thereof | PSMC1, PSME3, PSMB1 | TUBB4A 3522/4885TUBB 3243/4885TUBA3C 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.