Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.58 |
| ▸ | TUBB | P07437 | 4/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.58 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.58 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.58 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.58 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.58 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.58 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.58 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039976 | 0.89 | CA12 (0.58) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL2007007 | 0.88 | TNKS2 (0.68) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL7378487 | 0.87 | HTR2A (0.50) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL4464142 | 0.86 | HTR2A (0.75) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL23266383 | 0.86 | TUBB1 (0.63) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL7376461 | 0.85 | HTR2A (0.49) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL4740186 | 0.84 | TUBB4A (0.61) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL30504713 | 0.83 | HTR2A (0.55) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL4035285 | 0.83 | HTR2A (0.46) | HTR2AHTR2CHTR2BPTGS2TUBB4A | |
| SCHEMBL15240817 | 0.83 | TNKS2 (0.67) | HTR2AHTR2CHTR2BTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074777-A | Benzyl alcohol derivatives, preparation method and therapeutic use thereof | 赛诺菲 | 2017-08-18 | — | — | CN | claimed |
| EP-3746440-B1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | UNIV TEXAS (US) | 2023-07-05 | — | — | EP | disclosed |
| EP-3746440-B1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | UNIV TEXAS (US) | 2023-07-05 | — | — | EP | disclosed |
| US-11345659-B2 | Pipecolic esters for inhibition of the proteasome | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-05-31 | — | — | US | disclosed |
| US-11345659-B2 | Pipecolic esters for inhibition of the proteasome | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210002220-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2021-01-07 | — | — | US | disclosed |
| US-20210002220-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2021-01-07 | — | — | US | disclosed |
| EP-3746440-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | Board of Regents, The University of Texas System (US) | 2020-12-09 | — | — | EP | disclosed |
| WO-2019152527-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-08-08 | — | — | WO | disclosed |
| WO-2019152527-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-08-08 | — | — | WO | disclosed |
| EP-0515514-A1 | 2-ARALKOXY AND 2-ALKOXY ADENOSINE DERIVATIVES AS CORONARY VASODILATORS AND ANTIHYPERTENSIVE AGENTS | WHITBY RESEARCH, Inc. (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |
| US-5140015-A | Racemic mixture for inducing an adenosine response in humans and animals | WHITBY RESEARCH, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| US-5091531-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1992-02-25 | — | — | US | disclosed |
| WO-1991013082-A1 | 2-ARALKOXY AND 2-ALKOXY ADENOSINE DERIVATIVES AS CORONARY VASODILATORS AND ANTIHYPERTENSIVE AGENTS | WHITBY RESEARCH, INC. (US) | 1991-09-05 | — | — | WO | disclosed |
| US-5037827-A | Useful for treatment of disease caused by platelet activating factory | EISAI CO., LTD. (JP) | 1991-08-06 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |
| EP-0353474-A2 | Glycerin derivative and its pharmacological use | Eisai Co., Ltd. (JP) | 1990-02-07 | — | — | EP | disclosed |
| CN-1031532-A | HETEROCYCLIC COMPOUNDS | WELLCOME FOUND (GB) | 1989-03-08 | — | — | CN | disclosed |
| EP-0305093-A1 | Imidazo(1,2-b)pyridazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11345659-B2 | Pipecolic esters for inhibition of the proteasome | PSMG3, PSME3, PSMC1 | HTR2A 4751/4885HTR2C 4470/4885HTR2B 4762/4885 |
| US-20210002220-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | PSMG3, PSME3, PSMC1 | HTR2A 4751/4885HTR2C 4470/4885HTR2B 4762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.