Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205874 | 0.79 | NCF1 (0.40) | CTSSJAK2JAK1TYK2JAK3 | |
| SCHEMBL20147689 | 0.75 | JAK2 (0.38) | CTSSJAK2JAK1 | |
| SCHEMBL14836376 | 0.75 | CTSS (0.32) | CTSS | |
| SCHEMBL15606535 | 0.73 | NCF1 (0.34) | CTSSJAK2JAK1JAK3 | |
| SCHEMBL20070399 | 0.71 | HRH3 (0.34) | CTSSJAK2JAK1 | |
| SCHEMBL20205875 | 0.70 | JAK2 (0.31) | CTSSJAK2JAK1 | |
| SCHEMBL14836687 | 0.70 | GABRA1 (0.48) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL20147924 | 0.69 | UBE2M (0.34) | JAK2JAK1 | |
| SCHEMBL19195506 | 0.69 | IDO1 (0.31) | — | |
| SCHEMBL15604131 | 0.68 | CTSS (0.31) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |