Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153277 | 0.87 | CYP3A4 (0.56) | HPGDPOLBTSHRCYP3A4CYP2C9 | |
| SCHEMBL20148752 | 0.85 | USP2 (0.50) | HPGDPOLBTSHRCYP3A4CYP2C9 | |
| SCHEMBL23555266 | 0.84 | MMP9 (0.48) | HPGDPOLBTSHRCYP3A4CYP2C9 | |
| SCHEMBL20153275 | 0.84 | ALDH1A1 (0.54) | HPGDPOLBTSHRCYP3A4CYP2C9 | |
| SCHEMBL20631562 | 0.70 | HPGD (0.86) | HPGDPOLBTSHRMEN1KMT2A | |
| SCHEMBL20153274 | 0.70 | LMNA (0.50) | POLBTSHRSMN1; SMN2MAPK1CYP2D6 | |
| SCHEMBL21159018 | 0.69 | POLB (0.46) | HPGDPOLBMAPK1CYP1A2MEN1 | |
| SCHEMBL20148743 | 0.69 | GPR183 (0.51) | — | |
| SCHEMBL20153163 | 0.69 | GPR183 (0.53) | — | |
| SCHEMBL21078139 | 0.68 | OPRM1 (0.60) | POLBTSHRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |