Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22030558 | 0.88 | LMNA (0.46) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL20148580 | 0.87 | CHRM1 (0.47) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL23126238 | 0.86 | LMNA (0.45) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL18713211 | 0.83 | CHRM1 (0.58) | TSHRKDM4ECHRM1CHRM3NPC1 | |
| SCHEMBL18390255 | 0.82 | ROCK2 (0.55) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL20412808 | 0.82 | RET (0.46) | LMNATSHRALDH1A1KDM4EMAPT | |
| SCHEMBL20070962 | 0.81 | ROCK2 (0.56) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL890215 | 0.75 | ALDH1A1 (0.47) | ALDH1A1MAPTHTTKMT2ASLC6A2 | |
| SCHEMBL755746 | 0.75 | ALDH1A1 (0.50) | ALDH1A1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL18390270 | 0.75 | SMN1; SMN2 (0.46) | LMNAALDH1A1HTTSMN1; SMN2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |