Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070959 | 0.88 | LMNA (0.47) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL20148580 | 0.86 | CHRM1 (0.47) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL23126238 | 0.85 | LMNA (0.45) | LMNATSHRMAPK1RECQLNPSR1 | |
| SCHEMBL890215 | 0.74 | ALDH1A1 (0.47) | — | |
| SCHEMBL755746 | 0.74 | ALDH1A1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL7256377 | 0.73 | ALDH1A1 (0.46) | — | |
| SCHEMBL888869 | 0.72 | TRPM8 (0.45) | — | |
| SCHEMBL26162969 | 0.71 | GPX4 (0.39) | RETCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL20412808 | 0.71 | RET (0.46) | LMNATSHRRET | |
| SCHEMBL18713211 | 0.71 | CHRM1 (0.58) | TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |