SCHEMBL20072350

SCHEMBL20072350

CC(=S)OCCC1c2ccccc2-c2ccccc21

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.41
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40
POLB P06746 1/20 0.40
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
KMT2A Q03164 2/20 0.36
TDO2 P48775 1/20 0.36
FABP5 Q01469 3/20 0.35
FABP7 O15540 2/20 0.35
EPHX2 P34913 1/20 0.34
CYP1A2 P05177 1/20 0.33
GPR3 P46089 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20072237 0.83 POLB (0.51) HTR2APPARGPPARAPOLBCA1
SCHEMBL23840972 0.82 PPARG (0.40) HTR2APPARGPPARAPOLBCA1
SCHEMBL5932825 0.81 KMT2A (0.43) HTR2APPARGPPARAPOLBCA1
SCHEMBL5933473 0.77 PPARG (0.46) HTR2APPARGPPARAPOLBCA1
SCHEMBL5933468 0.77 KMT2A (0.43) HTR2APPARGPPARAPOLBCA1
SCHEMBL21553193 0.77 PPARG (0.46) HTR2APPARGPPARAPOLBCA1
SCHEMBL4056199 0.76 PPARG (0.42) HTR2APPARGPPARAPOLBCA1
SCHEMBL9328044 0.76 PPARG (0.42) HTR2APPARGPPARAPOLBCA1
SCHEMBL5932833 0.76 PPARG (0.42) HTR2APPARGPPARAPOLBCA1
SCHEMBL9328050 0.76 KMT2A (0.46) HTR2APPARGPPARAPOLBCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3526239-B1 HIF 1-ALPHA ANTISENSE OLIGONUCLEOTIDES OLIPASS CORP (KR) 2021-11-03 EP disclosed
US-11162104-B2 SCN9A antisense pain killer OLIPASS CORPORATION (KR) 2021-11-02 US disclosed
US-20190345202-A1 ANDROGEN RECEPTOR ANTISENSE OLIGONUCLEOTIDES OLIPASS CORPORATION (KR) 2019-11-14 US disclosed
US-20190337987-A1 EXON SKIPPING BY PEPTIDE NUCLEIC ACID DERIVATIVES OLIPASS CORPORATION (KR) 2019-11-07 US disclosed
WO-2018069764-A1 HIF 1-ALPHA ANTISENSE OLIGONUCLEOTIDES OLIPASS CORPORATION (KR) 2018-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190345202-A1 ANDROGEN RECEPTOR ANTISENSE OLIGONUCLEOTIDES AR, NR5A1, NR5A2 HTR2A 1606/4885PPARG 206/4885PPARA 142/4885
US-20190337987-A1 EXON SKIPPING BY PEPTIDE NUCLEIC ACID DERIVATIVES PTBP1, RBM17, UPF1 HTR2A 4665/4885PPARG 2473/4885PPARA 1687/4885
US-11162104-B2 SCN9A antisense pain killer SCN9A, SCN7A, SCN8A HTR2A 2578/4885PPARG 4485/4885PPARA 3472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.