SCHEMBL20076783

SCHEMBL20076783

C=C(Nc1ccc(F)c(NC(=C)C(F)F)c1F)c1cc(C)ccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.37
RAB9A P51151 4/20 0.33
PPARG P37231 2/20 0.33
PPARA Q07869 1/20 0.33
ABCB11 O95342 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
NR1I3 Q14994 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
TAS1R2 Q8TE23 1/20 0.33
SMN1; SMN2 Q16637 4/20 0.32
KMT2A Q03164 4/20 0.32
LMNA P02545 3/20 0.32
TP53 P04637 3/20 0.32
MAPT P10636 3/20 0.32
MEN1 O00255 3/20 0.32
ALDH1A1 P00352 3/20 0.32
NPC1 O15118 2/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20076509 0.92 KDM4E (0.36) KDM4ERAB9APPARGPPARAABCB11
SCHEMBL20077004 0.83 KDM4E (0.36) KDM4ERAB9APPARGPPARAABCB11
SCHEMBL20076423 0.81 KDM4E (0.41) KDM4ERAB9APPARGPPARATAS1R3
SCHEMBL21019686 0.80 RAB9A (0.42) KDM4ERAB9APPARGPPARATAS1R3
SCHEMBL20076766 0.78 KDM4E (0.41) KDM4ERAB9APPARGPPARAABCB11
SCHEMBL20076557 0.78
SCHEMBL20076564 0.77
SCHEMBL20076366 0.76 LMNA (0.31) KDM4EKMT2ALMNAMEN1ALDH1A1
SCHEMBL21020713 0.75 PTGS2 (0.41) KDM4ERAB9APPARGABCB11PTGS1
SCHEMBL21021625 0.73 RAB9A (0.41) KDM4ERAB9APPARGPPARATAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018071327-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-04-19 WO disclosed