Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.89 |
| ▸ | RET | P07949 | 5/20 | 0.89 |
| ▸ | EGFR | P00533 | 2/20 | 0.89 |
| ▸ | PLK4 | O00444 | 1/20 | 0.89 |
| ▸ | GAK | O14976 | 1/20 | 0.89 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.89 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.89 |
| ▸ | ERN1 | O75460 | 1/20 | 0.89 |
| ▸ | STK10 | O94804 | 1/20 | 0.89 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.89 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.89 |
| ▸ | ABL1 | P00519 | 1/20 | 0.89 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.89 |
| ▸ | LCK | P06239 | 1/20 | 0.89 |
| ▸ | FYN | P06241 | 1/20 | 0.89 |
| ▸ | CSF1R | P07333 | 1/20 | 0.89 |
| ▸ | YES1 | P07947 | 1/20 | 0.89 |
| ▸ | LYN | P07948 | 1/20 | 0.89 |
| ▸ | MET | P08581 | 1/20 | 0.89 |
| ▸ | HCK | P08631 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19668834 | 0.95 | KDR (0.86) | KDRRETEGFRPLK4GAK | |
| Cediranib SCHEMBL29368143 | 0.94 | KDR (1.00) | KDRRETEGFRPLK4GAK | |
| Cediranib SCHEMBL29351458 | 0.94 | KDR (1.00) | KDRRETEGFRPLK4GAK | |
| Cediranib SCHEMBL29383181 | 0.94 | KDR (1.00) | KDRRETEGFRPLK4GAK | |
| Cediranib SCHEMBL63147 | 0.94 | KDR (1.00) | KDRRETEGFRPLK4GAK | |
| SCHEMBL1685423 | 0.94 | ABCB11 (1.00) | KDRRETEGFRPLK4GAK | |
| SCHEMBL13471998 | 0.90 | KDR (0.89) | KDRRETEGFRPLK4GAK | |
| SCHEMBL3198096 | 0.90 | KDR (0.89) | KDRRETEGFRPLK4GAK | |
| SCHEMBL1401668 | 0.90 | KDR (0.89) | KDRRETEGFRPLK4GAK | |
| SCHEMBL1401641 | 0.90 | KDR (0.88) | KDRRETEGFRPLK4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10285991-B2 | Therapeutic compounds and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2019-05-14 | — | — | US | disclosed |
| US-20180104246-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | KALA BIO, Inc. | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10285991-B2 | Therapeutic compounds and uses thereof | MUC1, CFTR, SLC26A4 | KDR 4398/4885RET 2685/4885EGFR 1282/4885 |
| US-20180104246-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | MUC1, CFTR, SLC26A4 | KDR 4398/4885RET 2685/4885EGFR 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.