Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20078117 | 0.85 | LMNA (0.46) | LMNATSHRPIK3CBPOLBHTT | |
| SCHEMBL21183024 | 0.75 | PKM (0.45) | LMNATSHRPIK3CBHTTPKM | |
| SCHEMBL20078073 | 0.67 | PIK3CB (0.52) | LMNAPIK3CBPOLBHTTPIK3CA | |
| SCHEMBL8537283 | 0.65 | LMNA (0.61) | LMNATSHRPOLBHTTPKM | |
| SCHEMBL6625296 | 0.65 | PIK3CB (0.83) | PIK3CBHTTPIK3CAMTORPIK3CG | |
| SCHEMBL15386558 | 0.64 | PIK3CA (0.80) | PIK3CBPIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL8342797 | 0.63 | ALDH1A1 (0.55) | LMNATSHRPOLBPKMALDH1A1 | |
| SCHEMBL1444931 | 0.63 | TSHR (0.81) | LMNATSHRPOLBHTTPKM | |
| SCHEMBL19654590 | 0.62 | LMNA (0.53) | LMNATSHRPOLBHTTPKM | |
| SCHEMBL29592399 | 0.62 | PIK3CA (0.84) | PIK3CBPIK3CAMTORPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221307-B1 | NOVEL 1,3,5 -TRIAZINE BASED PI3K INHIBITORS AS ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2019-07-24 | — | — | EP | disclosed |
| US-9951040-B2 | 1,3,5 -triazine based PI3K inhibitors as anticancer agents and a process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-04-24 | — | — | US | disclosed |