Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.33 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLP1R | P43220 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19788777 | 0.87 | ALDH1A1 (0.41) | MAPTGAAALDH1A1S1PR2MEN1 | |
| SCHEMBL16006436 | 0.83 | AGPAT2 (0.37) | MAPTGAAALDH1A1AGPAT2MEN1 | |
| SCHEMBL24997637 | 0.83 | KMT2A (0.42) | MAPTGAAALDH1A1S1PR2MEN1 | |
| SCHEMBL22885167 | 0.80 | MAPT (0.33) | MAPTGAAALDH1A1AGPAT2MAPK1 | |
| SCHEMBL22885997 | 0.80 | — | — | |
| SCHEMBL20079062 | 0.78 | MEN1 (0.50) | ALDH1A1MEN1KMT2ANPC1KDM4E | |
| SCHEMBL19999745 | 0.77 | L3MBTL1 (0.37) | — | |
| SCHEMBL19788717 | 0.76 | CCR4 (0.33) | — | |
| SCHEMBL20079065 | 0.75 | CCR4 (0.33) | — | |
| SCHEMBL24999006 | 0.74 | HTT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951043-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |