Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16006435 | 0.86 | MEN1 (0.48) | MEN1KMT2ATDP1HPGDALDH1A1 | |
| SCHEMBL25639161 | 0.84 | CYP3A4 (0.39) | MEN1KMT2AHPGDALDH1A1TSHR | |
| SCHEMBL19788892 | 0.83 | HPGD (0.44) | MEN1KMT2AHPGDALDH1A1TSHR | |
| SCHEMBL25644750 | 0.81 | KDM4E (0.39) | MEN1KMT2ATDP1ALDH1A1NPC1 | |
| SCHEMBL19788777 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL20078890 | 0.78 | MAPT (0.33) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL24997637 | 0.77 | KMT2A (0.42) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL22885997 | 0.74 | — | — | |
| SCHEMBL19999745 | 0.71 | L3MBTL1 (0.37) | — | |
| SCHEMBL19788717 | 0.70 | CCR4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951043-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |