Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12420252 | 0.91 | POLB (0.47) | POLBKDM1AMAOAMAOBRCOR1 | |
| SCHEMBL25384390 | 0.86 | POLB (0.49) | POLBKDM1AMAOAMAOBRCOR1 | |
| SCHEMBL2175244 | 0.84 | POLB (0.53) | POLBKDM1AMAOAMAOBRCOR1 | |
| SCHEMBL25969568 | 0.81 | GHSR (0.32) | SMN1; SMN2KMT2AMEN1L3MBTL1 | |
| SCHEMBL18383469 | 0.77 | CTSB (0.49) | RAB9ASMN1; SMN2NPC1ALDH1A1L3MBTL1 | |
| SCHEMBL17772243 | 0.75 | AKT1 (0.33) | POLB | |
| SCHEMBL16868073 | 0.74 | MGLL (0.50) | TSHRKMT2AMEN1MGLL | |
| SCHEMBL2989044 | 0.74 | CTSS (0.56) | SMN1; SMN2ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL7043026 | 0.73 | POLB (0.62) | POLBKDM1AMAOAMAOBRCOR1 | |
| SCHEMBL5097407 | 0.72 | MIF (0.49) | POLBRAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9949981-B2 | Compositions and methods for treating proliferation disorders | ARQULE, INC. (US) | 2018-04-24 | — | — | US | disclosed |