Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | VNN1 | O95497 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14857219 | 0.92 | CHRM4 (0.36) | CHRM4FAAHTRPV1LRRK2PRKAA2 | |
| SCHEMBL202870 | 0.91 | CHRM4 (0.39) | CHRM4FAAHVNN1TRPV1PRKAA2 | |
| SCHEMBL2806168 | 0.88 | PRKAA2 (0.39) | VNN1LRRK2PRKAA2 | |
| SCHEMBL202538 | 0.82 | BDKRB1 (0.38) | CHRM4FAAHVNN1TRPV1LRRK2 | |
| SCHEMBL2805653 | 0.80 | CYP3A4 (0.40) | CHRM4LRRK2PRKAA2TTKALDH1A1 | |
| SCHEMBL186275 | 0.80 | BTK (0.38) | FAAHBTKVNN1TRPV1LRRK2 | |
| SCHEMBL2805532 | 0.80 | PRKAA2 (0.40) | CHRM4VNN1PRKAA2ALDH1A1LMNA | |
| SCHEMBL200796 | 0.80 | FAAH (0.33) | FAAHVNN1TRPV1LRRK2CHEK1 | |
| SCHEMBL13128434 | 0.80 | BDKRB1 (0.47) | VNN1LRRK2PRKAA2ALDH1A1LMNA | |
| SCHEMBL2805701 | 0.79 | BDKRB1 (0.41) | CHRM4PRKAA2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |