Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.73 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.73 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10948430 | 0.88 | PLOD2 (0.83) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL8053052 | 0.84 | PLOD2 (1.00) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL29249309 | 0.83 | KMT2A (0.62) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL17179998 | 0.83 | PLOD2 (0.68) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL5163555 | 0.80 | CYP3A4 (0.64) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL3108729 | 0.80 | PLOD2 (0.64) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL10843960 | 0.80 | NR4A2 (0.65) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL11366024 | 0.79 | L3MBTL1 (0.61) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL29664616 | 0.78 | PLOD2 (0.62) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 | |
| SCHEMBL28972977 | 0.78 | PLOD2 (0.62) | PLOD2CYP3A4CYP1A2CYP2C19PLOD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001014310-A1 | PLEUROMUTILIN β-KETOESTERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-03-01 | — | — | WO | claimed |
| US-20170152443-A1 | LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT | CHI MEI CORPORATION (TW) | 2017-06-01 | — | — | US | disclosed |
| US-20170152443-A1 | LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT | CHI MEI CORPORATION (TW) | 2017-06-01 | — | — | US | disclosed |
| EP-1926719-B1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-31 | — | — | EP | disclosed |
| US-9388175-B2 | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-07-12 | — | — | US | disclosed |
| CN-101993413-B | Method for preparing 4-pyridine propyl alcohol | SINOCHEM CORP | 2012-12-12 | — | — | CN | disclosed |
| EP-1881976-B1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC (US) | 2012-10-17 | — | — | EP | disclosed |
| US-20120070413-A1 | METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES | KIM TAE-SEONG (US) | 2012-03-22 | — | — | US | disclosed |
| US-8088794-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20110269748-A1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-11-03 | — | — | US | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |
| WO-2001070726-A1 | AMINOPHENYL PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | disclosed |
| EP-1136485-A1 | Aminophenyl pyrimidone derivatives | SANOFI-SYNTHELABO (FR) | 2001-09-26 | — | — | EP | disclosed |
| WO-2001046180-A2 | NOVEL DERIVATIVES OF 3-IMINO-1,2-DITHIOLES, METHOD FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | LES LABORATOIRES SERVIER (FR) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001014310-A1 | PLEUROMUTILIN β-KETOESTERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-03-01 | — | — | WO | disclosed |
| EP-0346208-B1 | 4-Amino quinolines and naphthyridines, process for their preparation and their use as medicaments | SANOFI ELF (FR) | 1994-04-13 | — | — | EP | disclosed |
| EP-0346208-A1 | 4-Amino quinolines and naphthyridines, process for their preparation and their use as medicaments | ELF SANOFI (FR) | 1989-12-13 | — | — | EP | disclosed |
| US-4474599-A | 1-(Pyridyl)-1H-1,2,3-triazole derivatives, and use as herbicidal agents | THE DOW CHEMICAL COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269748-A1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | CHRNA4, CHRNA5, CHRNA7 | PLOD2 2690/4885CYP3A4 410/4885CYP1A2 321/4885 |
| US-20120070413-A1 | METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES | HGF, HGFAC, MET | PLOD2 2380/4885CYP3A4 354/4885CYP1A2 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.