Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 2/20 | 0.47 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20081376 | 0.93 | HPD (0.49) | POLBTDO2IDO2HDAC1HDAC8 | |
| SCHEMBL16854205 | 0.90 | HDAC1 (0.55) | POLBPDE10ASMN1; SMN2ALDH1A1TDO2 | |
| SCHEMBL20081378 | 0.83 | ALOX12 (0.53) | POLBSMN1; SMN2ALDH1A1TDO2IDO2 | |
| SCHEMBL22238128 | 0.82 | USP2 (0.59) | PDE10ASMN1; SMN2ALDH1A1L3MBTL1USP2 | |
| SCHEMBL20081323 | 0.79 | PIK3CD (0.51) | POLBPDE10ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL18332822 | 0.78 | POLB (0.65) | POLBSMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL20404407 | 0.77 | ESR1 (0.44) | SMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL22237904 | 0.77 | PIK3CD (0.50) | SMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL20081212 | 0.77 | PDE10A (0.47) | PDE10ASMN1; SMN2LMNAMEN1PLA2G1B | |
| SCHEMBL15819051 | 0.76 | HTR7 (0.45) | PDE10AALDH1A1TDO2IDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312175-B1 | HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT | KOREA RES INST CHEMICAL TECH (KR) | 2020-07-22 | — | — | EP | disclosed |
| EP-3312175-A1 | HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT | Korea Research Institute of Chemical Technology (KR) | 2018-04-25 | — | — | EP | disclosed |