Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24486533 | 0.82 | KDM4E (0.42) | KDM4ETSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13498029 | 0.81 | KDM4E (0.46) | KDM4ETSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL17277363 | 0.80 | ACHE (0.43) | KDM4EALDH1A1KMT2A | |
| SCHEMBL12075463 | 0.78 | KDM4E (0.47) | KDM4ETSHRALDH1A1SMN1; SMN2GRM2 | |
| SCHEMBL12062257 | 0.77 | SOD1 (0.44) | KDM4ELMNAGRM2HTR1AHTR7 | |
| SCHEMBL12453902 | 0.76 | TAAR1 (0.47) | ALDH1A1 | |
| SCHEMBL13498042 | 0.75 | KDM4E (0.46) | KDM4ETSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL17277364 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4854291 | 0.74 | KDM4E (0.62) | KDM4ETSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10448057 | 0.73 | KDM4E (0.60) | KDM4ETSHRALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488525-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-04-25 | — | — | EP | disclosed |