Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SOD1 | P00441 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12075798 | 0.94 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 | |
| SCHEMBL17277363 | 0.81 | ACHE (0.43) | KDM4EALDH1A1L3MBTL1TDP1POLB | |
| SCHEMBL14771965 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 | |
| SCHEMBL20082425 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2TSHRGRM2 | |
| SCHEMBL12062257 | 0.78 | SOD1 (0.44) | KDM4ESOD1L3MBTL1POLBGRM2 | |
| SCHEMBL12453902 | 0.77 | TAAR1 (0.47) | ALDH1A1TDP1TAAR1MAOB | |
| SCHEMBL17277364 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL13185240 | 0.75 | ALDH1A1 (0.52) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 | |
| SCHEMBL3145987 | 0.74 | CYP11B1 (0.40) | MAPK1 | |
| SCHEMBL13463064 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | MPO, LPO, CAT | KDM4E 4344/4885ALDH1A1 1117/4885SMN1; SMN2 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.