Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17277363 | 0.94 | ACHE (0.43) | KDM4EL3MBTL1POLBTDP1ACHE | |
| SCHEMBL12075798 | 0.82 | KDM4E (0.48) | KDM4EL3MBTL1POLBTDP1ALDH1A1 | |
| SCHEMBL12062270 | 0.81 | SOD1 (0.42) | L3MBTL1POLBMAOB | |
| SCHEMBL20500756 | 0.81 | KDM4E (0.46) | KDM4EL3MBTL1ACHEADRB2ADRB1 | |
| SCHEMBL4210725 | 0.80 | TAAR1 (0.44) | TDP1ALDH1A1MAOB | |
| SCHEMBL19291481 | 0.78 | KDM4E (0.46) | KDM4EL3MBTL1ACHEADRB2ADRB1 | |
| SCHEMBL15075253 | 0.77 | ACHE (0.42) | KDM4EL3MBTL1POLBTDP1ACHE | |
| SCHEMBL3142728 | 0.76 | CHRNB2 (0.40) | — | |
| SCHEMBL12075463 | 0.76 | KDM4E (0.47) | KDM4EL3MBTL1POLBTDP1ALDH1A1 | |
| SCHEMBL13725526 | 0.76 | ACHE (0.47) | KDM4EL3MBTL1POLBTDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |